An unexepcted case lead Lee Yeon back in time to the year 1938 where he reencounters Ryu Hong Joo. Once a guardiang spirit of the mountain in the west, she's now the owner of a high-end restaurant in the capital city of Gyeongseong.He also meets his younger brother Lee Rang. Meenwhile, another former guardian spirit and ex-friend Cheon Moo Young has become hostile. Lee Yeon struggles to return to the present, to his loved one.

The third season follows the end of the second season of the Ishigaki Medical Foundation, depicting the evolution of Ishigaki Hospital and the growth of doctors three years later.